In 2015, 10.4 million cases of TB were estimated and, although only a small percentage (5вЂ“10%) develops the illness, its control has complicated due to the emergence of drug resistance strains. Tuberculosis (TB) has remained a serious health problem since Mycobacterium tuberculosis, the main agent of this disease, infects about one third population. tuberculosis, the analysis of gene expression to identify new markers of drug resistance strains, and the development of new antituberculosis drugs against drugвЂђresistant strains. In this chapter, we describe the most relevant mutations in genes associated with drug resistance in M. During this time, patients with TB are not adequately treated, and resistant strains may be transmitted to the rest of the population. tuberculosis strains based in cultures are laborious, timeвЂђconsuming and performed by specialized technicians, the result is generated until 4 months after receiving the samples.

Since the conventional methods to determine the identity of M. These mutations have become important in the design of earlyвЂђdiagnostic kits to identify the resistance profile of M. tuberculosis genome, together with the implementation of new molecular biology tools, has allowed the identification of changes in nucleic acid sequences with a functional impact. There is an increased transmission of Mycobacterium tuberculosis strains with drug resistance, hence complicating TB control.

Tuberculosis (TB) remains to be a serious health problem worldwide.

Super strain of tuberculosis